Absolutely. Same idea as my '64 EB-0 with one Dimarzio and one mudbucker...but you're gonna need to fill in a bit around the second pickup...
You're loaded for bear with that one.
http://www.vintageguitar.com/3353/kiss-able-gibson/
But the pickguard seems ok?
Yeah, something's definitely off with that headstock, yet it does look like it had banjo tuners. Could have been a prototype but not in that color.
Robert Plant and Jimmy Page (drummer and bassist of Deep Purple, Jake!)