I'm sure that if it were a duty weapon I'd have no problem with a Glock; by reputation they're well made and reliable, and a few hundred rounds through anything is enough to be well introduced.
Both my Diamondback and Model 28 are 4" barrel, which I have found to be a good general purpose length. Since the Model 28 is that big N-frame, it's almost too big for my hands. I use the Pachmayr rubber grips that don't cover the backstrap, as I can't afford to have the grips move my hand farther away from the trigger.
I have an S&W Model 34 ("Kit Gun") in .22, and it's very nice for practice. I also inherited my dad's late 40's Colt Officer's Model in 6" bbl and .22 caliber. It's beautifully made - you have to turn it in the light to see the joints between pieces of the frame. Fantastic fit.
And when I want to to say "what the hell", I have a 3-screw Ruger Blackhawk with 7.5" bbl. Nice handgun!
I do have a nice little Llama XV .22 semi-auto and a 1960's Ruger Mark II that are fun for plinking around.
And some rifles. Dang, I keep accumulating stuff.