Well I went and done it!
I bought a new pickguard for my Tele, alongside a Dimarzio Super Distortion T and a Pro Track for the neck. This vaguely follows the form of the Seymour Duncan JB + Jazz combo that goes into Seymour's Telegib creations. I suppose the tone will be different because blade 'hotrail' pickups sense a thinner slice of the string than a full-size pickup, but the effect is probably pretty minimal.
I've just received an ashtray bridge plate today, so maybe later tonight I will get that fitted. At the moment the Tele is running on the stock MIM bridge plate. Tonally the Super Distortion is way more powerful than the stock pickup, albeit quite compressed and with a very fast, hard attack. There still the classic Tele 'twang' in there, you just have to dial it out by rolling back the volume. The neck pickup is pretty much like a nice humbucker, and I've found nice jazzy tones in there. It stays clear under gain though, rather than resorting to mush. I always thought Teles make a good humbucker guitar, as you can adjust the overall power of the instrument with the volume control, and cycle from an over-bright tone to a darker Gibson tone using the tone control in conjunction with the volume control.