Considering the micro scale of this thing, string tension would not be the issue unless you used perhaps a 140 string as an E. I don't think you could tune this down to a bass EADG (it is not even made for a guitar EADGBE, I think it is supposed to be tuned even higher than a guitar at GDAE, tuning steps in fifths rather than fourths) and still hear an intonated note when fretting.
But to be honest: I've played with the idea too ...
Uwe