Growing up, we had a pair of Flemish Giant rabbits. Our buck(male) weighed in at a little over 22 pounds when I showed him for 4-H. They are very good-natured as long as you give them plenty of attention when they're small. You have to be careful when handling them as adults, though, because their hind legs are very strong and they have huge claws.
On a side note..... Domestic rabbit meat is delicious as long as it's young and you know how to cook it.