I ran GHS Precision Flats on my '78 4001 for several years, but came to the realization that I'm not a flats guy and went back to rounds. No troubles with the bass in that time, but I'm sure that could vary by specimen.
I should probably pay more attention to specs than I do, but I tend to just use the strings that I'm into at any given time (EXL-170s for the past decade or so). I figure the bass will gradually show signs if for some reason it couldn't cope... at which point I'd make a change if needed.